KMID : 1101420210530010032
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Korean Journal of Clinical Laboratory Science 2021 Volume.53 No. 1 p.32 ~ p.40
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Relationship between Hypertension and the Declining Renal Function in Korean Adults
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Lee Jun-Ho
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Abstract
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This study examined the association between hypertension (HTN), estimated glomerular filtration rate (eGFR), and urine microalbumin/creatinine ratio (ACR) in Korean adults. Data for 8,922 adults (3,941 men and 4,981 women) aged ¡Ã20 years from the Sixth Korean National Health and Nutrition Examination Survey VI (2013¡2014) were analyzed. In men, after adjusting for the related variables, the odds ratios (ORs) of HTN [systolic blood pressure (SBP) ¡Ã140 mmHg, diastolic blood pressure (DBP) ¡Ã90 mmHg, or use of HTN medications] were significantly higher in the decreased eGFR group [eGFR £¼60 mL/min/1.73 m2, 1.98 (95% CI, 1.21¡3.24)], elevated ACR group [ACR ¡Ã30 mg/g, 2.03 (95% CI, 1.54¡2.69)], and decreased eGFR plus elevated ACR group [eGFR £¼60 mL/min/1.73 m2 and ACR ¡Ã30 mg/g, 6.03 (95% CI, 2.82¡12.92)] than in the normal group (eGFR ¡Ã60 mL/min/1.73 m2 and ACR £¼30 mg/g). In women, after adjusting for the related variables, the ORs of HTN were significantly higher in the decreased eGFR group (2.29, 95% CI, 1.27¡4.13), elevated ACR group (2.22, 95% CI, 1.68¡2.94), and decreased eGFR plus elevated ACR group (10.77, 95% CI, 3.89¡29.82) than the normal group. In conclusion, HTN was associated with a decreased eGFR and elevated ACR in Korean men and women. In addition, the prevalence of HTN increased greatly when a decreased eGFR and elevated ACR occurred simultaneously.
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KEYWORD
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Hypertension, Estimated glomerular filtration rate, Urine microalbumin/creatinine ratio, Chronic kidney disease, Albuminuria
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